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Coronary Blood Flow
In humans the resting coronary blood flow averages 225ml/min, which is 4 to 5 percent of the total cardiac output. The blood flow in the left ventricle falls to a low value during systole, because of strong compression of intramuscular vessels by the myocardial contraction. During diastole, however, the cardiac muscle relaxes and no longer obstructs the blood flow through the left ventricular blood vessels. Coronary blood flow increases rapidly during diastole. The force of contraction of right ventricle is much less than that of the left ventricle. The phasic changes in blood flow are relatively small compared with those in the left ventricle.
Oxygen demand or consumption is a major factor in regulation of coronary blood flow, while the neural control is of secondary importance. Among metabolites known, adenosine is thought to be the most important. It plays a role in the regulation of coronary blood flow