ããçé
¸å
æéç´ å¼èµ·è¿æååºï¼å¯è§ç®ç¹ãçççï¼å¶è§è¨éº»ç¹ãè¡ç®¡æ§æ°´è¿åè¡æ¸
ç
ååºçï¼ç½è§å¥è±æ§ç®çã大ç±æ§ç®çãå¤å½¢æ§çº¢æåSteven-Johnson综åå¾ã
ããçé
¸å
æéç´ è注å¼èµ·è¿ææ§ä¼å
çå¯è½æ§å¾å°.è¥ä¸å
¶å®è¯é
å使ç¨,æç¹å¼ä½è´¨å°±é¾è¯´äº.
ããé:çé
¸å
æéç´ æ³¨å°æ¶²è¯´æ书
ãããè¯åå称ã
ããéç¨åï¼çé
¸å
æéç´ æ³¨å°æ¶²
ããåååï¼
ããè±æåï¼Clindamycin Hydrochloride Injection
ããæ±è¯æ¼é³ï¼Yansuan Kelinmeisu Zhusheye
ããæ¬å主è¦æå为çé
¸å
æéç´ ï¼å
¶åå¦å为6-ï¼1-ç²åº-å-4-ä¸åº-L-2-å¡å¯ç·ç²é
°æ°¨åºï¼-1-硫代-7ï¼Sï¼-æ°¯-6ï¼7ï¼8-ä¸è±æ°§-L-èå¼-α-D-åä¹³è¾å¡åç³è·çé
¸çãå
¶
ããåå¦ç»æå¼ä¸ºï¼
ããååå¼ï¼ C18H33ClN2O5S·HCl
ããååéï¼ 461.44
ãããæ§ç¶ã
ããæ¬å为
ãããè¯çæ¯çã
ããæ¬åå±æå¯éç´ ç±»æçç´ ã为æå¯éç´ çè¡çç©ï¼æèè°±ä¸æå¯éç´ ç¸åï¼æèæ´»æ§è¾æå¯éç´ å¼º4ï½8åã对é©å
°é³æ§èå¦è¡èçèå±ï¼å
æ¬èééç´ æ ªï¼ãé¾çèå±ãç½åæèãçç½æèçæè¾é«æèæ´»æ§ã对é©å
°é´æ§åæ°§èä¹æè¯å¥½æèæ´»æ§ï¼ææèå±å
æ¬èå¼±ææèãæ¢æèå±ãæ¶åçèãæ¶åé¾çèã产æ°èèæèç大å¤å¯¹æ¬åé«åº¦ææãé©å
°é´æ§éæ°§èå
æ¬æµæåè¡æèãå¥çèå±åæ¯åä½å±å对æ¬åèè¯ãæ¬åä¸ééç´ ãæ°¯éç´ ã头å¢èç´ ç±»ååç¯ç´ ç±»ä¹é´æ 交åèè¯ï¼ä¸å¤§ç¯å
é
¯ç±»æé¨å交åèè¯ï¼ä¸æå¯éç´ æå®å
¨äº¤åèè¯æ§ã
ããæ¬åçä½ç¨æºå¶æ¯ä¸ç»èæ ¸ç³ä½50Säºåºç»åï¼é»æ¢è½é¾ç延é¿ï¼ä»èæå¶ç»èç»èçèç½è´¨åæãæ¬åç³»æèè¯ï¼ä½å¨é«æµåº¦æ¶ï¼å¯¹æäºç»èä¹å
·ææèä½ç¨ã
ãããè¯ä»£å¨åå¦ã
ããæ¬åèå
注å°åè¡è¯æµåº¦è¾¾å³°æ¶é´ï¼tmaxï¼ï¼æ人约为3å°æ¶ï¼å¿ç«¥çº¦ä¸º1å°æ¶ãéè注å°æ¬å300mgï¼10åéè¡è¯æµåº¦ä¸º7 mg/Lã表è§åå¸å®¹ç§¯ï¼Vdï¼çº¦ä¸º94Lãæ¬åçèç½ç»åçé«ï¼ä¸º92%-94%ãæ¬åä½å
åå¸å¹¿æ³ï¼å¯è¿å
¥å¾æ¶²ãç°ãå¼å¸ç³»ç»ãè¸è
积液ãèæ±ãååè
ºãèèãèè±ãéå°¾ã精液ã软ç»ç»ã骨åå
³èçï¼ä¹å¯éè¿èçï¼ä½ä¸æè¿å
¥èè液ä¸ãå¨éª¨ç»ç»ãèæ±å尿液ä¸å¯è¾¾é«æµåº¦ãæ¬åå¨èè代谢ï¼é¨å代谢ç©å¯ä¿çæèæ´»æ§ã代谢ç©ç±èæ±å尿液ææ³ã约10%ç»è¯é以活æ§æåç±å°¿æåºï¼å
¶ä½ä»¥ä¸å
·æ´»æ§ç代谢产ç©æåºãè¡æ¶é¤åè¡°æï¼T1/2βï¼çº¦ä¸º3å°æ¶ï¼èãè¾åè½ä¸å
¨è
t1/2βå¯ç¥æ延é¿ãè¡æ¶²éæåè
¹èéæä¸è½æ¸
é¤æ¬åã
ãããéåºçã
ããæ¬åéç¨äºé¾çèå±ãè¡èçèå±ååæ°§èï¼å
æ¬èå¼±ææèã产æ°èèæèãæ¾çº¿èçï¼æè´çä¸ãéææï¼å¦å¸å
¥æ§èºçãèè¸ãèºèè¿ã骨é«çãè
¹è
ææãçè
ææåè´¥è¡ççã
ãããç¨æ³ç¨éã
ããèå
注å°æéè滴注ã
ããæ人 ä¸æ¥0.6ï½1.2gï¼å2ï½4次åºç¨ï¼ä¸¥éææï¼ä¸æ¥1.2ï½2.4gï¼å2ï½4次éè滴注ã
ãã4å¨å4å¨ä»¥ä¸å°å¿ ä¸æ¥15ï½25mg/kgï¼å3ï½4次åºç¨ï¼ä¸¥éææï¼ä¸æ¥25ï½40mg/ kgï¼å3ï½4次åºç¨ã
ããæ¬åèå
注å°ç容é1次ä¸è½è¶
è¿600mgï¼è¶
è¿æ¤å®¹éåºæ¹ä¸ºéèç»è¯ãéèç»è¯é度ä¸å®è¿å¿«ï¼600mgçæ¬ååºå å
¥ä¸å°äº100mlçè¾æ¶²ä¸ï¼è³å°æ»´æ³¨20åéã1å°æ¶å
è¾å
¥çè¯éä¸è½è¶
è¿1200mgã
ãããä¸è¯ååºã
ãã1ï¼èè éååºï¼å¸¸è§æ¶å¿ãååãè
¹çãè
¹æ³»çï¼ä¸¥éè
æè
¹ç»çãè
¹é¨åçã严éè
¹æ³»ï¼æ°´æ ·æèè¡æ ·ï¼ï¼ä¼´åçãå¼å¸¸å£æ¸´åç²ä¹ï¼åèæ§è çï¼ãè
¹æ³»ãè çååèæ§è çå¯åçå¨ç¨è¯åæï¼ä¹å¯åçå¨åè¯åæ°å¨ã
ãã2ï¼è¡æ¶²ç³»ç»ï¼å¶å¯åçç½ç»èåå°ãä¸æ§ç²ç»èåå°ãåé
¸æ§ç²ç»èå¢å¤åè¡å°æ¿åå°çï¼ç½è§åçéç¢æ§è´«è¡ã
ãã3ï¼è¿æååºï¼å¯è§ç®ç¹ãçççï¼å¶è§è¨éº»ç¹ãè¡ç®¡æ§æ°´è¿åè¡æ¸
ç
ååºçï¼ç½è§å¥è±æ§ç®çã大ç±æ§ç®çãå¤å½¢æ§çº¢æåSteven-Johnson综åå¾ã
ãã4ï¼èãè¾åè½å¼å¸¸ï¼å¦è¡æ¸
æ°¨åºè½¬ç§»é
¶åé«ãé»ç¸çã
ãã5. éè滴注å¯è½å¼èµ·éèçï¼èå
注å°å±é¨å¯è½åºç°ç¼çã硬ç»åæ èæ§èè¿ã
ãã6. å
¶ä»ï¼è³é¸£ãç©æã念ç èææçã
ãããç¦å¿çã
ãã对æ¬ååæå¯éç´ ç±»è¿æè
ç¦ç¨ã
ããã注æäºé¡¹ã
ãã1ï¼ä¸åæ
åµåºæ
ç¨ï¼(1) èè éç¾ç
æææ¢å¾å²è
ï¼ç¹å«å¦æºç¡æ§ç»è çãå±éæ§è çææçç´ ç¸å
³è çï¼æ¬åå¯å¼èµ·åèæ§è çï¼ã(2)èåè½åéã(3)è¾åè½ä¸¥éåéã(4)æå®åæå
¶ä»è¿æå²è
ã
ãã2ï¼å¯¹æ¬åè¿ææ¶æå¯è½å¯¹å
¶ä»å
æéç´ ç±»ä¹è¿æã
ãã3ï¼å¯¹å®éªå®¤æ£æ¥ææ çå¹²æ°ï¼æè¯åè¡æ¸
ä¸æ°¨é
¸æ°¨åºè½¬ç§»é
¶åé¨å¬æ°¨é
¸æ°¨åºè½¬ç§»é
¶å¯æå¢é«ã
ãã4ï¼ç¨è¯æé´éå¯å注æ大便次æ°ï¼å¦åºç°æ便次æ°å¢å¤ï¼åºæ³¨æåèæ§è ççå¯è½ï¼éåæ¶åè¯å¹¶ä½éå½å¤çãè½»çæ£è
åè¯åå³å¯è½æ¢å¤ï¼ä¸çè³éçæ£è
éè¡¥å
æ°´ãçµè§£è´¨åèç½è´¨ãå¦ç»ä¸è¿°å¤çæ æï¼ååºå£æç²ç¡å250ï½500mgï¼ä¸æ¥3次ãå¦å¤åï¼å¯å次å£æç²ç¡åï¼ä»æ ææ¶å¯æ¹ç¨ä¸å¤éç´ (æè
å»ç²ä¸å¤éç´ )å£æï¼ä¸æ¬¡125ï½500mgï¼æ¯6å°æ¶1次ï¼çç¨5ï½10æ¥ã
ãã5ï¼ä¸ºé²æ¢æ¥æ§é£æ¹¿ççåçï¼ç¨æ¬åæ²»ç溶è¡æ§é¾çèæææ¶ï¼çç¨è³å°ä¸º10æ¥ã
ãã6ï¼æ¬åå¶å°ä¼å¯¼è´ä¸ææå¾®çç©çè¿åº¦ç¹æ®æå¼èµ·äºéææï¼ä¸æ¦åçäºéææï¼åºç«å³åè¯å¹¶éåç¸åºæªæ½ã
ãã7ï¼çç¨é¿è
ï¼éå®ææ£æµèãè¾åè½åè¡å¸¸è§ã
ãã8. 严éè¾åè½åéåï¼æï¼ä¸¥éèåè½åéï¼ä¼´ä¸¥é代谢å¼å¸¸è
ï¼éç¨é«åéæ¶éè¿è¡è¡è¯æµåº¦çæµã
ãã9.æ¬åä¸è½éè¿è¡-èè液å±éï¼æ
ä¸è½ç¨äºèèçã
ãã10.ä¸åç»è对æ¬åçæææ§å¯æç¸å½å¤§çå·®å¼ï¼æ
è¯æè¯éªæéè¦æä¹ã
ãããåå¦ååºä¹³æå¦å¥³ç¨è¯ã
ãã1. å¨ç©å®éªæ¾ç¤ºæ¬å对èå¿æ å½±åï¼ä½åºç¨äºåå¦å°ç¼ºä¹ç»éªï¼ä¸æ¬åå¯éè¿èçï¼æ
åå¦æ
ç¨ã
ãã2. æ¬åå¯åæ³è³æ¯ä¹³ä¸ï¼æ
åºä¹³æå¦å¥³æ
ç¨ï¼ä½¿ç¨æ¬åæ¶æååºä¹³ã
ãããå¿ç«¥ç¨è¯ã
ããåºç4å¨ä»¥å
çå©´å¿ç¦ç¨æ¬åãå
¶ä»å°å¿æç¨æ¬åæ¶åºæ³¨æè§å¯éè¦å¨å®çåè½ã
ãããèå¹´æ£è
ç¨è¯ã
ããæ£æ严éåºç¡ç¾ç
çè年人æåçè
¹æ³»æåèæ§è ççä¸è¯ååºï¼ç¨è¯æ¶éå¯åè§å¯ã
ãããè¯ç©ç¸äºä½ç¨ã
ãã1ï¼æ¬åå¯å¢å¼ºå¸å
¥æ§éº»éè¯çç¥ç»èèé»æç°è±¡ï¼å¯¼è´éª¨éª¼è软弱åå¼å¸æå¶æ麻ç¹ï¼å¼å¸æåï¼ï¼å¨ææ¯ä¸ææ¯ååç¨æ¶åºæ³¨æã以æè碱é
¯é
¶è¯ç©æéçæ²»çå¯æææã
ãã2ï¼æ¬åä¸æè å¨æ¢æ³»è¯ãå«ç½é¶åæ¢æ³»è¯åç¨ï¼å¨çç¨ä¸çè³å¨çç¨åæ°å¨æå¼èµ·ä¼´ä¸¥éæ°´æ ·è
¹æ³»çåèæ§è çå¯è½ãå å¯ä½¿ç»è å
æ¯ç´ 延è¿æåºï¼ä»è导è´è
¹æ³»å»¶é¿åå å§ï¼æ
æ¬åä¸å®ä¸æè å¨æ¢æ³»è¯åç¨ãä¸å«ç½é¶åæ¢æ³»è¯åç¨æ¶ï¼æ¬åçå¸æ¶å°æ¾èåå°ï¼æ
两è
ä¸å®åæ¶æç¨ï¼éé´éä¸å®æ¶é´ï¼è³å°2å°æ¶ï¼ã
ãã3ï¼æ¬åå
·ç¥ç»èèé»æä½ç¨ï¼å¯å¢å¼ºç¥ç»èèé»æè¯çä½ç¨ï¼ä¸¤è
åºé¿å
åç¨ãæ¬åä¸æèæ åè¯åç¨æ¶å°å¯¼è´åè
对骨骼èçææåå¼±ï¼ä¸ºæ§å¶éçèæ åççç¶ï¼å¨åç¨æ¶æèæ åè¯çåéåºäºè°æ´ã
ãã4ï¼æ°¯éç´ æ红éç´ å¨é¶ä½ä¸åå¯ç½®æ¢æ¬åï¼æé»ææ¬åä¸ç»èæ ¸ç³ä½50Säºåºçç»åï¼ä½å¤è¯éªæ¾ç¤ºæ¬åä¸çº¢éç´ å
·æ®æä½ç¨ï¼æ
æ¬åä¸å®ä¸æ°¯éç´ æ红éç´ åç¨ã
ãã5ï¼ä¸é¿çç±»éçè¯åç¨æ¶ï¼æ¬åçå¼å¸æå¶ä½ç¨ä¸é¿çç±»çä¸æ¢å¼å¸æå¶ä½ç¨å¯å ç¸å èæ导è´å¼å¸æå¶å»¶é¿æå¼èµ·å¼å¸éº»ç¹ï¼å¼å¸æåï¼çå¯è½ï¼æ
å¿
须对ç
人è¿è¡å¯åè§å¯æçæ¤ã
ãã6. æ¬åä¸å®å å
¥ç»ä»½å¤æçè¾æ¶²ä¸ï¼ä»¥å
åçé
ä¼ç¦å¿ã
温馨提示:答案为网友推荐,仅供参考