1. What's the matter with you; 2.What's come over you 3. What is wrong with you 4.What happened to you 5.What's the deal with you? 6.What's bothering you?
1. What's the matter with you? 2.What's come over you? 3. What is wrong with you? 4.What happened to you? 5.What's the deal with you? 6.What's bothering you? 7.What‘s the problem with you? 8.Is there anything wrong with you?