背景:来自wikipedia, In the Class-II locus, each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3, -4 o -5). That means that one heterozygous individual can inherit 6 or 8 Class-II alleles, three or four from each progenitor.
问1:
根据nature网站关于HLA complex的描述,(http://www.nature.com/ki/journal/v56/n5/fig_tab/4491085f1.html)我认为wiki上这段文字应该改成:
wikipedia, In the Class-II locus, each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB4 o -5) or three genes (DRB1 and DRB2 and DRB3) . That means that one heterozygous individual can inherit 6 ~10 Class-II alleles, 3~5 from each progenitor. 是这样吗?
(当同源染色体分别是DR3,DR5,DR6其中之一时,MHC II 基因为10个)
问2:DR2 单体基因型含有B2 和B5基因,细胞会否经过重排最后只有B2 或者B5留在染色体上?另外,HLA的MHC II的3个基因座DP,DQ,DR会否重排最后只留下一个座的基因来翻译MHC II?
问3:
我认为这篇wiki 和这篇nature上用allele这个词没用对
wiki :one heterozygous individual can inherit 6 or 8 Class-II alleles
nature:DRB1,DRB5 and DQ alleles on DR2 haplotype in Caucasians.
等位基因才是allele,但是DRB1,DRB5 and DQ根本不等位,因此,这两处的 alleles应该用genes来表达,对吗?